The surprising finding answers a longstanding question and has
immediate implications for developing treatments, researchers said. And they
suspect that other degenerative brain diseases like Parkinson’s may spread in a
similar way.
Alzheimer’s researchers have long known that dying, tau-filled
cells first emerge in a small area of the brain where memories are made and
stored. The disease then slowly moves outward to larger areas that involve
remembering and reasoning.
But for more than a quarter-century, researchers have been
unable to decide between two explanations. One is that the spread may mean that
the disease is transmitted from neuron to neuron, perhaps along the paths that
nerve cells use to communicate with one another. Or it could simply mean that
some brain areas are more resilient than others and resist the disease longer.
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